Education

• Medical Education: Medical University of Gdansk 1989-1996
• Post-Doctoral Training: New York State Institute for Basic Research 1996-1998
• Internship: Manhattan VA Hospital (Medicine) 1998-1999
• Residency Training: St. Vincent Hospital (Neurology) 1999-2000; NYU Medical Center 2000-2002

About Dr. Sadowski

Dr. Sadowski specializes in General adult neurology, mild cognitive impairment, memory disorders, Alzheimer's disease, and dementia.

Dr. Sadowski graduated from Medical University of Gdansk in Gdansk, Poland in 1995 and received Ph.D. in neuroanatomy from the same institution in 1996. Between 1996 and 1998 he completed post-doctoral fellowship in experimental neuropathology in the New York State Institute for Basic Research. Following an internship in general medicine, Dr. Sadowski completed a neurology residency in New York Medical College and NYU School in Medicine and joined NYU faculty as an Assistant Professor in 2002. Dr. Sadowski research focuses on Alzheimer's disease, the most common form of dementia, and on prion diseases, which although relatively rare grasp a broad attention of the general public. Both Alzheimer's disease and prion disease belong to a group of conformational disorders where pathological mechanism lies upon conversion of physiological proteins into insoluble and toxic conformers accumulating in the brain during the course of the disease. Dr. Sadowski is using cell culture and transgenic animal models to study various aspects of pathological mechanisms of these diseases. He is also using these models to test various diagnostic and treatment approaches which may be applicable for human use. In particular Dr. Sadowski is working on inhibition an interaction between amyloid-beta peptide and apolipoprotein E which chaperones conformational transformation of amyloid-beta and facilitates its deposition in the brain of Alzheimer's patients. Developed by Dr. Sadowski ligands that block the apolipoprotein E/amyloid-beta interaction were shown to successfully lower amount of amyloid-beta deposited in brains of Alzheimer's transgenic mice. Dr. Sadowski is also developing new MRI and PET ligands allowing detection of accumulation of abnormal prion protein in infected but presymptomatic patients. Dr. Sadowski is recipient of a career development award from the National Institute on Aging and the Paul B. Beeson Career Development Award in Studies on Aging Clinical research of Dr. Sadowski focuses on memory dysfunction during normal aging, mild cognitive impairment and its conversion to Alzheimer's disease.

Diseases and conditions treated

• Alzheimer's Disease
• Mild Cognitive Impairment
• Vascular Dementia
• Fronto-temporal Dementia
• Age-associated Memory Loss
• Neurodegenerative disorders resulting in cognitive impairment