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Thomas Wisniewski, MD

Dowjat WK, Wisniewski HM, Wisniewski T. (2001). Alzheimer’s disease presenilin-1 expression modulates the assembly of neurofilaments. Neuroscience, 103: 1-8.

Sigurdsson EM, Scholtzova H, Mehta PD, Frangione B, Wisniewski T. (2001). Immunization with a non-toxic/non-fibrillar amyloid- homologous peptide reduces Alzheimer’ disease associated pathology in transgenic mice. American Journal of Pathology, 159: 439-447.

Ji Y, Permanne B, Sigurdsson EM, Holtzman DM, Wisniewski T. (2001). Amyloid ß 40/42 clearance across the blood-brain barrier following intra-ventricular injections in wild-type, apoE knock-out and human apoE3 or E4 expressing transgenic mice. Journal of Alzheimer’s Disease, 3: 23-30,

Aucouturier P, Geissmann F, Saborio G, Meeker HC, Damotte D, Kascsak R, Kascsak R, Carp RI, Wisniewski T. (2001).Scrapie neuroinvasion in RAG-10/0 mice by transfer of infected splenic dendritic cells. Journal of Clinical Investigation, 108: 703-708.

Golabek AA, Kida E, Walus M, Perez C, Wisniewski T, Soto C. (2000). Sodium dodecyl suphate-resistant complexes of Alzheimer’s amyloid - ß peptide with the N-terminal, receptor binding domain of apolipoprotein E. Biophysical Journal; 79: 1008-1015.

Aucouturier P, Carp RI, Carnaud C, Wisniewski T. (2000). Prion disease and the immune system. Clin.Immunol.; 96: 79-85.

Stoltzner SE, Grenfell TJ, Mori C, Wisniewski KE, Wisniewski TM, Selkoe DJ and Lemere CA. (2000). Temporal Accrual of Complement Proteins in Amyloid Plaques in DS with Alzheimer’s Disease. Am J.Pathol,156: 489-499.

Soto C, Kascsak RJ, Saborio GP, Aucouturier P, Wisniewski T, Prelli F, Kascsak R, Mendez E, Kumar A, Harris DA, Ironside J, Tagliavini F, Carp RI, Frangione B. (2000). Reversion of prion protein conformational changes by synthetic ß-sheet breaker peptides. The Lancet, 355: 192-197.

Sigurdsson EM, Permanne B, Soto C, Wisniewski T, (2000). Frangione B. In Vivo Reversal of Amyloid ß Lesions in Rat Brain, Journal of Neuropathology and Experimental Neurology, 59: 11-17.

Dowjat WK, Wisniewski T, Efthimiopoulos S, Wisniewski HM. (1999). Inhibition of neurite outgrowth by Familial Alzheimer’s disease linked presenilin-1 mutations. Neuroscience Letters, 267: 141-144.

 

Pomara N., Shao B., Wisniewski T., Mehta P. D. (1998). Decreases in plasma A1-40 levels with aging in non-demented elderly with ApoE-epsilon 4 allele. Neurochem.Res. 23 (12):1563-1566,.

Wisniewski T, Aucouturier P, Frangione B. (1998). The prion related disorders. Amyloid, 5: 212-224.

Askanas V, King Engel W, Chih-Chao Y, Alvarez RB, Lee YMY, Wisniewski T. (1998). Light and electron microscopic immunolocalization of presenilin 1 in abnormal muscle fibers of patients with sporadic inclusion body myositis and autosomal recessive inclusion body myopathy. Am. J. Pathol. 152:889-895.

Wisniewski T, Dowjat WK, Buxbaum JD, Khorhova O, Efthimiopoulos S, Kulczycki J, Lojkowska W, Wegiel J, Wisniewski HM, Frangione B. (1998). A novel Polish presenilin-1 mutation (P117L) is associated with familial Alzheimer’s disease and leads to death as early as age 28 years. NeuroReport, 9:217-221.

Permanne B, Perez C, Soto C, Frangione B, Wisniewski T. (1997).Detection of apolipoprotein E/ dimeric soluble ß complexes in Alzheimer’s disease brain supernatants. Biochem. Biophys. Res. Commun., 240: 715-720.

Wisniewski T, Dowjat W, Permanne B, Palha J, Kumar A, Gallo G, Frangione B. (1997). Presenilin is associated with Alzheimer’s disease amyloid. Am. J. Pathol., 151: 601-610.

Ghiso J, Calero M, Matsubara E, Governale S, Chuba J, Beavis R, Wisniewski T, Frangione B. (1997). Alzheimer’s soluble amyloid ß is a normal component of urine. FEBS Lett., 408: 105-108.

Lalowski M, Golabek A, Lemere CA, Selkoe DJ, Wisniewski HM, Beavis RC, Frangione B, Wisniewski T. (1996). The "non amyloidogenic" p3 fragment (amyloid ß17-42) is a major constituent of Down syndrome cerebellar preamyloid. J. Biol. Chem., 271:33623-33631.

Golabek A, Soto C, Vogel T, Wisniewski T. (1996).The interaction between apolipoprotein E and Alzheimer's Amyloid ß-peptide is dependent on ß-peptide conformation. J.Biol. Chem. 271: 10602-10606.

Lemere CA, Blusztajn JK, Yamaguchi H, Wisniewski T, Saido T, Selkoe D. (1996). Sequence of deposition of heterogeneous amyloid ß-peptides and apolipoprotein E in Down syndrome: Implications for initial events in amyloid plaque formation. Neurobiol. Dis., 3:16-32.

Baumann MH, Golabek H, Lalowski M, Wisniewski T. (1996). Micropreparative gel electrophoresis of small molecular weight peptides: purification of highly insoluble amyloid peptide fragments. Anal. Biochem., 236:191-198.

Soto C, Golabek A, Wisniewski T, Castano EM. (1996). Alzheimer's soluble ßamyloid is conformationally modified by apolipoprotein E in vitro. Neuroreport, 7:721-725.

 

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