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Thomas Wisniewski, MD
Dowjat WK, Wisniewski
HM, Wisniewski T. (2001). Alzheimers disease presenilin-1 expression
modulates the assembly of neurofilaments. Neuroscience, 103:
1-8.
Sigurdsson EM,
Scholtzova H, Mehta PD, Frangione B, Wisniewski T. (2001). Immunization
with a non-toxic/non-fibrillar amyloid- homologous peptide reduces
Alzheimer disease associated pathology in transgenic mice. American
Journal of Pathology, 159: 439-447.
Ji Y, Permanne
B, Sigurdsson EM, Holtzman DM, Wisniewski T. (2001). Amyloid ß
40/42 clearance across the blood-brain barrier following intra-ventricular
injections in wild-type, apoE knock-out and human apoE3 or E4 expressing
transgenic mice. Journal of Alzheimers Disease, 3: 23-30,
Aucouturier P,
Geissmann F, Saborio G, Meeker HC, Damotte D, Kascsak R, Kascsak R,
Carp RI, Wisniewski T. (2001).Scrapie neuroinvasion in RAG-10/0
mice by transfer of infected splenic dendritic cells. Journal
of Clinical Investigation, 108: 703-708.
Golabek AA, Kida
E, Walus M, Perez C, Wisniewski T, Soto C. (2000). Sodium dodecyl suphate-resistant
complexes of Alzheimers amyloid - ß peptide with the N-terminal,
receptor binding domain of apolipoprotein E. Biophysical Journal;
79: 1008-1015.
Aucouturier P,
Carp RI, Carnaud C, Wisniewski T. (2000). Prion disease and the immune
system. Clin.Immunol.; 96: 79-85.
Stoltzner
SE, Grenfell TJ, Mori C, Wisniewski KE, Wisniewski TM, Selkoe DJ and
Lemere CA. (2000). Temporal Accrual of Complement Proteins
in Amyloid Plaques in DS with Alzheimers Disease. Am J.Pathol,156:
489-499.
Soto C, Kascsak
RJ, Saborio GP, Aucouturier P, Wisniewski T, Prelli F, Kascsak R, Mendez
E, Kumar A, Harris DA, Ironside J, Tagliavini F, Carp RI, Frangione
B. (2000). Reversion of prion protein conformational changes by synthetic
ß-sheet breaker peptides. The Lancet, 355: 192-197.
Sigurdsson EM,
Permanne B, Soto C, Wisniewski T, (2000). Frangione B. In Vivo Reversal
of Amyloid ß Lesions in Rat Brain, Journal of Neuropathology
and Experimental Neurology, 59: 11-17.
Dowjat WK, Wisniewski
T, Efthimiopoulos S, Wisniewski HM. (1999). Inhibition of neurite outgrowth
by Familial Alzheimers disease linked presenilin-1 mutations.
Neuroscience Letters, 267: 141-144.
Pomara N., Shao
B., Wisniewski T., Mehta P. D. (1998). Decreases in plasma A1-40
levels with aging in non-demented elderly with ApoE-epsilon 4 allele.
Neurochem.Res. 23 (12):1563-1566,.
Wisniewski T, Aucouturier
P, Frangione B. (1998). The prion related disorders. Amyloid,
5: 212-224.
Askanas V, King
Engel W, Chih-Chao Y, Alvarez RB, Lee YMY, Wisniewski T. (1998). Light
and electron microscopic immunolocalization of presenilin 1 in abnormal
muscle fibers of patients with sporadic inclusion body myositis and
autosomal recessive inclusion body myopathy. Am. J. Pathol. 152:889-895.
Wisniewski T, Dowjat
WK, Buxbaum JD, Khorhova O, Efthimiopoulos S, Kulczycki J, Lojkowska
W, Wegiel J, Wisniewski HM, Frangione B. (1998). A novel Polish presenilin-1
mutation (P117L) is associated with familial Alzheimers disease
and leads to death as early as age 28 years. NeuroReport, 9:217-221.
Permanne B, Perez
C, Soto C, Frangione B, Wisniewski T. (1997).Detection of apolipoprotein
E/ dimeric soluble ß complexes in Alzheimers disease brain
supernatants. Biochem. Biophys. Res. Commun., 240: 715-720.
Wisniewski T, Dowjat
W, Permanne B, Palha J, Kumar A, Gallo G, Frangione B. (1997). Presenilin
is associated with Alzheimers disease amyloid. Am. J. Pathol.,
151: 601-610.
Ghiso J, Calero
M, Matsubara E, Governale S, Chuba J, Beavis R, Wisniewski T, Frangione
B. (1997). Alzheimers soluble amyloid ß is a normal component
of urine. FEBS Lett., 408: 105-108.
Lalowski M, Golabek
A, Lemere CA, Selkoe DJ, Wisniewski HM, Beavis RC, Frangione B, Wisniewski
T. (1996). The "non amyloidogenic" p3 fragment (amyloid ß17-42)
is a major constituent of Down syndrome cerebellar preamyloid. J.
Biol. Chem., 271:33623-33631.
Golabek A, Soto
C, Vogel T, Wisniewski T. (1996).The interaction between apolipoprotein
E and Alzheimer's Amyloid ß-peptide is dependent on ß-peptide
conformation. J.Biol. Chem. 271: 10602-10606.
Lemere CA, Blusztajn
JK, Yamaguchi H, Wisniewski T, Saido T, Selkoe D. (1996). Sequence
of deposition of heterogeneous amyloid ß-peptides and apolipoprotein
E in Down syndrome: Implications for initial events in amyloid plaque
formation. Neurobiol. Dis., 3:16-32.
Baumann MH, Golabek
H, Lalowski M, Wisniewski T. (1996). Micropreparative gel electrophoresis
of small molecular weight peptides: purification of highly insoluble
amyloid peptide fragments. Anal. Biochem., 236:191-198.
Soto C, Golabek
A, Wisniewski T, Castano EM. (1996). Alzheimer's soluble ßamyloid
is conformationally modified by apolipoprotein E in vitro. Neuroreport,
7:721-725.
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